R-universe - detlew (Detlew Labes)

PowerTOST - Power and Sample Size for (Bio)Equivalence Studies

Contains functions to calculate power and sample size for various study designs used in bioequivalence studies. Use known.designs() to see the designs supported. Power and sample size can be obtained based on different methods, amongst them prominently the TOST procedure (two one-sided t-tests). See README and NEWS for further information.

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9.85 score 22 stars 4 dependents 180 scripts 1.4k downloads

Power2Stage - Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies

Contains functions to obtain the operational characteristics of bioequivalence studies in Two-Stage Designs (TSD) via simulations.

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3.11 score 1 stars 13 scripts 233 downloads

randomizeBE - Create a Random List for Crossover Studies

Contains a function to randomize subjects, patients in groups of sequences (treatment sequences). If a blocksize is given, the randomization will be done within blocks. The randomization may be controlled by a Wald-Wolfowitz runs test. Functions to obtain the p-value of that test are included. The package is mainly intended for randomization of bioequivalence studies but may be used also for other clinical crossover studies. Contains two helper functions sequences() and williams() to get the sequences of commonly used designs in BE studies.

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1.60 score 2 stars 6 scripts 207 downloads