Package: Power2Stage 0.5-4.9000

Power2Stage: Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies

Contains functions to obtain the operational characteristics of bioequivalence studies in Two-Stage Designs (TSD) via simulations.

Authors:Detlew Labes [aut, cre], Benjamin Lang [aut, ctb], Helmut Schütz [aut, ctb]

# Install 'Power2Stage' in R:

install.packages('Power2Stage', repos = c('https://detlew.r-universe.dev', 'https://cloud.r-project.org'))

On CRAN:

Last updated from:f934963e58. Checks:7 WARNING, 2 OK. Indexed: yes.

Target	Result	Time
linux-devel-x86_64	WARNING	150
source / vignettes	OK	168
linux-release-x86_64	WARNING	118
macos-release-arm64	WARNING	158
macos-oldrel-arm64	WARNING	133
windows-devel	WARNING	114
windows-release	WARNING	112
windows-oldrel	WARNING	95
wasm-release	OK	116

Help page	Topics
Analysis after second stage of 2-stage 2x2 crossover design based on the Inverse Normal method	final.2stage.in final.tsd.in
Interim analysis of first stage data of 2-stage 2x2 crossover designs based on the Inverse Normal method	interim.2stage.in interim.tsd.in
Power calculation of adaptive 2-stage BE studies in a 2x2 crossover design	power.2stage power.tsd
Power calculation of adaptive 2-stage BE studies (2x2 crossover) with a futility criterion for the point estimate of T/R or its 90% CI	power.2stage.fC power.tsd.fC
Power calculation for non-adaptive group sequential (2-stage) BE studies	power.2stage.GS power.tsd.GS
Power calculation of adaptive 2-stage BE studies with 2x2 crossover design, based on the Inverse Normal method	power.2stage.in power.tsd.in
Power calculation of adaptive 2-stage BE studies (2x2 crossover) (variant of power.2stage to obtain the results of Karalis / Macheras)	power.2stage.KM power.tsd.KM
Power calculation of adaptive 2-stage BE studies in 2-group parallel designs	power.2stage.p power.2stage.pAF power.tsd.p power.tsd.pAF
Power of 2-stage BE studies in 2x2 crossover designs with interim sample size re-estimation	power.2stage.ssr power.tsd.ssr
Sample size re-estimation of adaptive 2-stage BE studies in 2x2 crossover and parallel designs based on power of TOST	sampleN2.TOST